CorPhylaxis

Our award-winning science

A new level of precision
for the healing heart.

Our founding research asks a fundamental question: how can we address the biology that worsens heart injury without compromising the repair that keeps the heart intact?

The biological challenge

Preserve the essential scar.
Address the injury beyond it.

Essential structural repair, harmful fibrosis and rupture risk explain why cellular specificity matters.

Heart muscleScar and fibrotic tissue
Cutaway of the heart with a localized structural scar replacing damaged muscle and maintaining an intact ventricular wall

Repair that protects.

A structural scar replaces lost muscle and helps keep the ventricular wall intact.

The same cardiac cutaway with fibrosis extending beyond the essential scar into surviving heart muscle

Fibrosis that harms.

Excessive fibrosis can extend into surviving muscle, contributing to adverse remodeling and heart failure.

A compromised scar with a full-thickness fissure through the left ventricular wall, illustrating rupture risk

When repair fails.

Disrupting essential repair can weaken the wall and cause catastrophic cardiac rupture.

Contrasting outcomes after myocardial infarction. Rupture risk from impaired repair is demonstrated in experimental models.

The discovery

Different cells.
Different consequences.

Following myocardial infarction, scar formation provides essential structural support. Excessive or persistent remodeling can also damage surviving tissue and contribute to heart failure.

Broad intervention risks disrupting both processes. Experimental studies show that compromising repair can weaken the ventricular wall and lead to cardiac rupture.

Using our human heart data engine, we identified distinct cell subpopulations with opposing roles: some exacerbate injury, while others protect the healing heart.

Our therapeutic philosophy follows from that discovery: understand the cellular context, selectively address the disease-driving biology, and preserve protective repair.

Awards and selections

Recognized by the
cardiovascular community.

  • Innovative Project Award

    American Heart Association

    Competitive research support for the founding science.

  • Louis N. and Arnold M. Katz Basic Science Research Prize — Top 5

    American Heart Association · Scientific Sessions 2025

    Selected among the Top 5 to present discoveries in cardiovascular basic science. View the AHA program.

  • Top 5 Ventures

    AHA Innovation Forum

    Selected to present as one of five ventures.

  • Top 15 ventures

    Deerfield & Cure · MEHA II

    Selected for the healthcare venture program.

  • NIH Catalyze grant finalist

    National Heart, Lung, and Blood Institute

    Two projects reached the finalist stage, as reported in the company’s November 2026 materials. Finalist status is not a grant award.

Selected publications

Built on a published
scientific record.

Founder-authored work spanning post-infarction remodeling, cardiac repair and spatial biology.

  • CirculationAccepted
    Research highlight

    Cell-state-specific protection in the remodeling infarcted heart

    Manuscript accepted · related abstract published November 2025

    An accepted manuscript on the cellular programs that protect the healing heart. Related work was presented in a published 2025 Circulation abstract.

    Authors of the published abstractPublication author list; the linked journal record provides the full citation.
    Read the 2025 abstract
  • Cardiovascular Research2026
    Research highlight

    Macrophage biology, angiogenesis and post-infarction remodeling

    Published online · 6 October 2026

    Experimental work examining how macrophage signaling connects vascular repair, extracellular-matrix remodeling and cardiac function after infarction.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
  • Frontiers in Cell and Developmental Biology2026

    Decoding cardiac homeostasis and injury: the evolving landscape of spatial transcriptomics

    A perspective on how spatial biology helps resolve the cellular environments of cardiac injury and repair.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
  • Journal of Molecular and Cellular Cardiology2024

    Macrophages in the infarcted heart acquire a fibrogenic phenotype, expressing matricellular proteins, but do not undergo fibroblast conversion

    Research examining cellular identity and matrix-related function in the healing heart.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
  • Circulation2023

    Cardiac pericytes acquire a fibrogenic phenotype and contribute to vascular maturation after myocardial infarction

    A study of the relationship between cardiac mural cells, tissue remodeling and vascular maturation after injury.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
  • Matrix Biology2021

    Collagen denaturation in the infarcted myocardium involves temporally distinct effects of MT1-MMP-dependent proteolysis and mechanical tension

    First-authored research investigating how collagen remodeling changes across the inflammatory, proliferative and maturation phases of infarct healing.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
  • AJP–Heart and Circulatory Physiology2020

    Validation of diagnostic criteria and histopathological characterization of cardiac rupture in the mouse model of nonreperfused myocardial infarction

    First-authored work on structural integrity and the experimental assessment of cardiac rupture.

    AuthorsPublication author list; the linked journal record provides the full citation.
    Read publication
Explore the publication record

These publications provide scientific context. They do not establish the clinical efficacy of a CorPhylaxis therapy.

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